Ipamorelin and CJC 1295 are almost always discussed together in research circles, and the reason comes down to receptor pharmacology. The two peptides work through entirely different but complementary mechanisms that produce a Ipamorelin is a pentapeptide. Five amino acids. That's it. But three of those five don't exist in nature. The sequence: Aib His D 2 Nal D Phe Lys, with a C terminal amide. Position 1 is aminoisobutyric acid the Effects of Excess Cortisol and Hypercortisolism A smarter way to boost natural growth hormone: CJC 1295 + Ipamorelin work together to signal your pituitary to release your own growth hormone (GH), rather than introducing synthetic GH. CJC 1295 = The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol ScienceDirect