Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome Scientific Reports Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert! Coptidis Rhizoma Alkaloids Alleviate Acetaminophen Induced Liver Injury by Regulating GSH Metabolism and the TNF Signaling Pathway Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.