Management of Athletes With G6PD Deficiency: Does Missing an Enzyme Mean Missing More Games? Shane N. Stone, Karl V. Reisig, Heather L. Saffel, Christopher M. Miles, 2020 Blister Cell in G6PD Deficiency , Red Blood Cell with a clear vacuole like area on its membrane, resembling a blister., It usually results when splenic macrophages remove precipitated Heinz G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( Diabetes causes inhibition of glucose 6 phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex American Journal of Physiology Renal Physiology American Physiological Society Treatment strategies for glucose 6 phosphate dehydrogenase deficiency: past and future perspectives: Trends in Pharmacological Sciences